Cry1^em1Lijd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cry1^em1Lijd
• Name: cryptochrome circadian regulator 1; endonuclease-mediated mutation 1, Jia-Da Li
• MGI ID: MGI:8240382
• Synonyms: Cry1delta11
• Gene: Cry1 Location: Chr10:84967564-85020918 bp, - strand Genetic Position: Chr10, 41.63 cM, cytoband C
• Alliance: Cry1^em1Lijd page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated an A to C change at position 1717 (c.1717 + 3A>C) corresponding the human c.1657 +3A>C mutation that destroys the exon 11 splice donor site and leads to mis-splicing, skipping exon 11. Western blot analysis confirmed the production of a truncated exon 11 deleted protein. (J:371309)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cry1 Mutation: 38 strains or lines available

References

• Original: J:371309 Liu D, et al., Cry1Delta11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling. JCI Insight. 2023 Aug 22;8(16)
• All: 1 reference(s)