Phenotypes Associated with This Genotype

Genotype
MGI:8210948

• Allelic Composition: Tmtc4^em1Dkc/Tmtc4^em1Dkc; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:351171 )

• auditory brainstem response (ABR) threshold shows elevation at P19 with a further increase at P24 and P28

nonsyndromic hearing loss ( J:351171 )

• mice exhibit profound hearing loss after auditory onset (after P15)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive nonsyndromic deafness		DOID:0050565	OMIM:607197 OMIM:PS220290	J:351171