Tmtc4^em1Dkc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmtc4^em1Dkc
• Name: transmembrane and tetratricopeptide repeat containing 4; endonuclease-mediated mutation 1, Dylan K Chan
• MGI ID: MGI:8210905
• Synonyms: Tmtc4^fl
• Gene: Tmtc4 Location: Chr14:123156383-123220697 bp, - strand Genetic Position: Chr14, 66.04 cM, cytoband E5
• Alliance: Tmtc4^em1Dkc page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was flanked by loxP sites via CRISPR-targeting. (J:351171)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmtc4 Mutation: 42 strains or lines available

References

• Original: J:351171 Li J, et al., TMTC4 is a hair cell-specific human deafness gene. JCI Insight. 2023 Dec 22;8(24)
• All: 1 reference(s)