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Phenotypes Associated with This Genotype
Genotype
MGI:8210943
Allelic
Composition		 Tmtc4em1Dkc/Tmtc4em1Dkc
Myo15atm1.1(cre)Ugds/Myo15a+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo15atm1.1(cre)Ugds mutation (0 available); any Myo15a mutation (138 available)
Tmtc4em1Dkc mutation (0 available); any Tmtc4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
cochlear hair cell degeneration ( J:351171 )
• mice exhibit intact hair cells through P30 but partial hair cell loss in all 3 cochlear turns at P45
increased or absent threshold for auditory brainstem response ( J:351171 )
• auditory brainstem response (ABR) threshold shows elevation at P19 with a further increase at P24 and P28
increased or absent distortion product otoacoustic emission threshold ( J:351171 )
• distortion product otoacoustic emissions (DPOAEs) threshold is normal at auditory onset but thresholds are elevated in adult (older than P26) mice
nonsyndromic hearing loss ( J:351171 )
• mice exhibit normal ABRs and DPOAEs at auditory onset (P13) but show rapid progression to complete deafness by P26

nervous system
cochlear hair cell degeneration ( J:351171 )
• mice exhibit intact hair cells through P30 but partial hair cell loss in all 3 cochlear turns at P45

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 122 DOID:0070669 OMIM:620714
 J:351171

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory