Phenotypes Associated with This Genotype

Genotype
MGI:7624379

• Allelic Composition: Kcnt1^em1Lekk/Kcnt1⁺
• Genetic Background: C57BL/6J-Kcnt1^em1Lekk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:287751 )

N • normal behavior in open field test

seizures ( J:287751 )

• spontaneous electrographic seizures and persistent interictal spikes

increased susceptibility to pharmacologically induced seizures ( J:287751 )

• convulsive (phase 3) seizures after PTZ administration

nervous system

seizures ( J:287751 )

• spontaneous electrographic seizures and persistent interictal spikes

increased susceptibility to pharmacologically induced seizures ( J:287751 )

• convulsive (phase 3) seizures after PTZ administration

mortality/aging

mortality/aging ( J:287751 )

N • normal survival

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
developmental and epileptic encephalopathy 14		DOID:0080439	OMIM:614959	J:287751