Phenotypes Associated with This Genotype

Genotype
MGI:7580966

• Allelic Composition: Mtif3^{tm1c(EUCOMM)Wtsi}/Mtif3^{tm1c(EUCOMM)Wtsi}; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

thin interventricular septum ( J:287609 )

• found at 25 weeks of age

increased heart weight ( J:287609 )

• increased heart weight/tibial length

decreased heart left ventricle posterior wall thickness ( J:287609 )

• thin left ventricular posterior wall (LVPW) found at 25 weeks of age

decreased cardiac muscle contractility ( J:287609 )

• decreased fractional shortening found at 25 weeks of agefound at 25 weeks of age

cardiomyopathy ( J:287609 )

• cellular disarray and necrotic foci found in cardiac tissue at 10 and 25 weeks of age

growth/size/body

increased heart weight ( J:287609 )

• increased heart weight/tibial length

decreased body weight ( J:287609 )

• mice are significantly lighter compared to control mice starting at 3 weeks of age to 25 weeks

muscle

decreased cardiac muscle contractility ( J:287609 )

• decreased fractional shortening found at 25 weeks of agefound at 25 weeks of age

cardiomyopathy ( J:287609 )

• cellular disarray and necrotic foci found in cardiac tissue at 10 and 25 weeks of age

decreased skeletal muscle fiber size ( J:287609 )

• decreased size of specific fibers in the skeletal muscle of 25-week-old knockout mice

centrally nucleated skeletal muscle fibers ( J:287609 )

• centralized nuclei in the skeletal muscle of 25-week-old knockout mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:287609