Phenotypes Associated with This Genotype

Genotype
MGI:7571249

• Allelic Composition: Dsg2^em1Spin/Dsg2⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal intercalated disk morphology ( J:342765 )

• increased ICD volume in heart owing to increased width between cells

abnormal heart right ventricle wall morphology ( J:342765 )

• fibrotic and calcified areas in myocardium

cardiac fibrosis ( J:342765 )

decreased right ventricle systolic pressure ( J:342765 )

• reduced fractional shortening

irregular heartbeat ( J:342765 )

• right ventricular arrhythmia

ventricular premature beat ( J:342765 )

♂

abnormal QRS complex ( J:342765 )

• increased QRS interval

decreased QRS amplitude ( J:342765 )

• decreased S peak amplitude

cellular

decreased keratinocyte adhesion ( J:342765 )

integument

decreased keratinocyte adhesion ( J:342765 )

muscle

abnormal intercalated disk morphology ( J:342765 )

• increased ICD volume in heart owing to increased width between cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arrhythmogenic right ventricular cardiomyopathy		DOID:0050431	OMIM:PS107970	J:342765