Phenotypes Associated with This Genotype

Genotype
MGI:7518241

• Allelic Composition: Chd7^{tm2c(EUCOMM)Wtsi}/Chd7^{tm2c(EUCOMM)Wtsi}; Tg(Neurod1-cre)RZ24Gsat/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NTac
• Cell Lines: EPD0019_1_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:314588 )

• most show moderate hearing loss

nervous system

abnormal vestibulocochlear ganglion morphology ( J:314588 )

• rapid degeneration of neurons between P1 and P7, reducing numbers to 50% that of controls

neuron degeneration ( J:314588 )

• rapid degeneration of spiral ganglion neurons between P1 and P7, reducing numbers to 50% that of controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
CHARGE syndrome		DOID:0050834	OMIM:214800	J:314588