Phenotypes Associated with This Genotype

Genotype
MGI:7439148

• Allelic Composition: Iigp1c^em1Btlr/Iigp1c^em1Btlr
• Genetic Background: C57BL/6J-Iigp1c^em1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:333470 )

N • mice fed a high-fat diet exhibit normal glucose metabolism and serum levels of total cholesterol, LDL, and HDL

abnormal lipid oxidation ( J:333470 )

• decreased in the livers of mice fed a high-fat diet

increased circulating triglyceride level ( J:333470 )

• small in mice fed a high-fat diet

increased circulating alanine transaminase level ( J:333470 )

• in mice fed a standard chow or a high-fat diet

decreased liver free fatty acids level ( J:333470 )

• in mice fed a high-fat diet

increased liver triglyceride level ( J:333470 )

• in mice fed a standard chow or a high-fat diet

liver/biliary system

increased liver weight ( J:333470 )

• in mice fed a standard chow

decreased liver free fatty acids level ( J:333470 )

• in mice fed a high-fat diet

increased liver triglyceride level ( J:333470 )

• in mice fed a standard chow or a high-fat diet

hepatic steatosis ( J:333470 )

• in mice fed a high-fat diet

growth/size/body

growth/size/body region phenotype ( J:333470 )

N • mice fed a high-fat diet exhibit normal weight

increased liver weight ( J:333470 )

• in mice fed a standard chow

cellular

abnormal lipid oxidation ( J:333470 )

• decreased in the livers of mice fed a high-fat diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
metabolic dysfunction-associated steatotic liver disease		DOID:0080208	OMIM:613282 OMIM:613387	J:333470