Phenotypes Associated with This Genotype

Genotype
MGI:7413047

• Allelic Composition: Chd8^tm1Kei/Chd8⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased brain weight ( J:235128 )

• brain weight is increased at E18.5

increased prepulse inhibition ( J:235128 )

• mice exhibit increased prepulse inhibition for 74- or 78-dB prepulses before a 120-dB startle stimulus

behavior/neurological

increased anxiety-related response ( J:235128 )

• mice spend less time in the light chamber for the light-dark transition test, in the open arms for the elevated plus-maze test, and in the center of the open-field indicating increased anxiety

decreased startle reflex ( J:235128 )

• mice show a lower acoustic startle response

abnormal social investigation ( J:235128 )

• mice show reduced number of social contacts in the social-interaction test but an increase in the duration per contact, resulting in an increase in total contact time

• however, the total duration of active contacts such as sniffing and following behavior is reduced

growth/size/body

megacephaly ( J:235128 )

• brain weight and volume are increased indicating macrocephaly

digestive/alimentary system

decreased intestine length ( J:235128 )

• mice have shorter intestine

abnormal intestinal transit time ( J:235128 )

• mice tend to show slower intestinal transit

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:235128