Phenotypes Associated with This Genotype

Genotype
MGI:7408192

• Allelic Composition: Ts(17¹⁶)65Dn/0
• Genetic Background: involves: BALB/c * C3H/He * C57BL/6JEiJ * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:331897 )

asthenozoospermia ( J:331897 )

reduced male fertility ( J:331897 )

• only 3 fertile males out of 39 tested

behavior/neurological

impaired contextual conditioning behavior ( J:331897 )

• lower level of responses in a fear conditioning test compared with wild-type mice

impaired spatial learning ( J:331897 )

• in the learning and reversal phase, mice take longer mice to reach the platform in a Morris water maze than wild-type

• more severe than in Ts(17¹⁶)66Yah mice

abnormal spatial working memory ( J:331897 )

• lower percentage of spontaneous alterations in a Y-maze test

increased thigmotaxis ( J:331897 )

• reduced travel in the center of an open field

• in a Morris water maze

abnormal response to novel object ( J:331897 )

• mice spend more time exploring a novel object compared with wild-type mice

hyperactivity ( J:331897 )

• mice travel greater distance in an open field and in the light and dark phases

• increased number of Y-maze arm entries

increased vertical activity ( J:331897 )

• even in the habituation phase

• however, rearing the center of an open field is decreased

abnormal nest building behavior ( J:331897 )

• impaired nest building behavior

craniofacial

small cranium ( J:331897 )

• with more pronounced deformations than in Ts(17¹⁶)66Yah mice

nervous system

abnormal brain morphology ( J:331897 )

• more severe than in Ts(17¹⁶)66Yah mice

skeleton

small cranium ( J:331897 )

• with more pronounced deformations than in Ts(17¹⁶)66Yah mice

cellular

oligozoospermia ( J:331897 )

asthenozoospermia ( J:331897 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:331897