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Phenotypes Associated with This Genotype
Genotype
MGI:7311738
Allelic
Composition
Rarres1tm1.2Mhl/Rarres1tm1.2Mhl
Genetic
Background
involves: 129S1/SvImJ * C57BL/6 * FVB/N * NIH Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rarres1tm1.2Mhl mutation (0 available); any Rarres1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 77.8% life-time incidence of follicular lymphoma
• lymphoma onset is first detected around 1 year of age
• in some mice, follicular lymphoma shows widespread organ involvement including the liver, mesenteric lymph nodes, inguinal lymph nodes, spleen, pancreas, and cervical lymph nodes
• high grade aggressive follicular lymphoma has characteristics of diffuse large B-cell lymphoma
• however, mice do not show increased incidence of epithelial cancers

immune system
• B cells are maintained in a less differentiated state
• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced plasma cell differentiation
• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced germinal center B cell formation
• B cells accumulate at the G0/G1 phase of the cell cycle after 3 days of T cell-dependent activation thus there is an increased number of B cells in G0/G1 and fewer in S and G2/M
• B cells show a small but significant decrease in the levels of NAD+
• however, B cells do not alter mitochondrial oxidative phosphorylation after 24 hours of T cell-dependent activation
• resting B cells undergo slightly decreased levels of apoptosis, but the magnitude of protection from apoptosis is not commensurate with the increase in cell viability
• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show decreased IgG1 production, reduced germinal center B cell formation, and reduced plasma cell differentiation
• resting (unstimulated) B cells are more viable after 3 days in culture while 3-day T cell-dependent activated B cells show only a marginal increase in viability

hematopoietic system
• B cells are maintained in a less differentiated state
• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced plasma cell differentiation
• mice show survival of CD45+ cells within the liver up to 3 months postnatally suggesting extramedullary hematopoiesis even after birth
• however, mature blood cell and hematopoietic stem progenitor cell (HSPC) numbers are normal, with no changes in T cells and B cells, numbers of macrophages, granulocytes, NK cells, and plasma cells, and normal levels of multipotent progenitor cells and
• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show reduced germinal center B cell formation
• B cells accumulate at the G0/G1 phase of the cell cycle after 3 days of T cell-dependent activation thus there is an increased number of B cells in G0/G1 and fewer in S and G2/M
• B cells show a small but significant decrease in the levels of NAD+
• however, B cells do not alter mitochondrial oxidative phosphorylation after 24 hours of T cell-dependent activation
• resting B cells undergo slightly decreased levels of apoptosis, but the magnitude of protection from apoptosis is not commensurate with the increase in cell viability
• splenic B cells activated in vitro by stimulation with anti-IgM, anti-CD40, and IL-4 (modeling T cell-dependent activation in B cells) show decreased IgG1 production, reduced germinal center B cell formation, and reduced plasma cell differentiation
• resting (unstimulated) B cells are more viable after 3 days in culture while 3-day T cell-dependent activated B cells show only a marginal increase in viability

cellular
• mouse embryonic fibroblasts (MEFs) exhibit increased levels of basal/maximum oxygen consumption, ATP production, and spare respiratory capacity
• resting B cells undergo slightly decreased levels of apoptosis, but the magnitude of protection from apoptosis is not commensurate with the increase in cell viability
• resting (unstimulated) B cells are more viable after 3 days in culture while 3-day T cell-dependent activated B cells show only a marginal increase in viability

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
follicular lymphoma DOID:0050873 OMIM:151430
J:324270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory