Rarres1^tm1.2Mhl
Targeted Allele Detail

Summary

• Symbol: Rarres1^tm1.2Mhl
• Name: retinoic acid receptor responder (tazarotene induced) 1; targeted mutation 1.2, Mi-Hye Lee
• MGI ID: MGI:7311668
• Gene: Rarres1 Location: Chr3:67386305-67422856 bp, - strand Genetic Position: Chr3, 30.99 cM
• Alliance: Rarres1^tm1.2Mhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324270
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeted KO-first, conditional ready, lacZ-tagged mutant vector PRPGS00072_A_A02 from the KOMP project 39930 was obtained from UC Davis KOMP-CSD and was used to insert an FRT site followed by, splice acceptor site, IRES, lacZ sequence with polyadenylation sequence, and a loxP site, followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site into intron 2 of the gene. A third loxP site is inserted into intron 3. The critical exon is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene and cre-mediated recombination deleted exon 3 in the germline. (J:324270)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarres1 Mutation: 13 strains or lines available

References

• Original: J:324270 Patel J, et al., Loss of RARRES1 function Promotes Follicular Lymphomagenesis and Inhibits B cell Differentiation in Mice. Int J Biol Sci. 2022;18(7):2670-2682
• All: 1 reference(s)