Phenotypes Associated with This Genotype

Genotype
MGI:6782396

• Allelic Composition: Cchcr1^em1Aoka/Cchcr1^em1Aoka
• Genetic Background: C57BL/6NJcl-Cchcr1^em1Aoka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:309941 )

N • normal presence of hair follicles in alopecic areas

alopecia ( J:309941 )

• hair loss patches after birth in 55% of mice

• number and size of hair loss patches increases over time

• varied location of hair loss

brittle hair ( J:309941 )

• broken hair in alopecic areas

abnormal hair shaft morphology ( J:309941 )

• tapered hair in alopecic areas

abnormal hair cuticle ( J:309941 )

• abnormal (irregular) cuticle morphology in both normal and alopecic areas but more pronounced in latter

immune system

immune system phenotype ( J:309941 )

N • no lymphocyte infiltration in alopecic areas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alopecia areata		DOID:986	OMIM:104000 OMIM:610753	J:309941