Phenotypes Associated with This Genotype

Genotype
MGI:6731445

• Allelic Composition: Spred1^{em1(IMPC)Ccpcz}/Spred1^{em1(IMPC)Ccpcz}
• Genetic Background: C57BL/6N-Spred1^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Spred1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased thigmotaxis ( J:211773 )

IMPC - CCP-IMG

increased freezing behavior ( J:211773 )

IMPC - CCP-IMG

abnormal startle reflex ( J:211773 )

IMPC - CCP-IMG

tremors ( J:211773 )

IMPC - CCP-IMG

decreased grip strength ( J:211773 )

IMPC - CCP-IMG

decreased locomotor activity ( J:211773 )

♀

IMPC - CCP-IMG

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

craniofacial

abnormal cranium morphology ( J:211773 )

♂

IMPC - CCP-IMG

abnormal tooth morphology ( J:211773 )

IMPC - CCP-IMG

abnormal mandible morphology ( J:211773 )

♂

IMPC - CCP-IMG

abnormal maxilla morphology ( J:211773 )

IMPC - CCP-IMG

abnormal zygomatic bone morphology ( J:211773 )

IMPC - CCP-IMG

abnormal snout morphology ( J:211773 )

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - CCP-IMG

small seminal vesicle ( J:211773 )

♂

IMPC - CCP-IMG

abnormal ovary morphology ( J:211773 )

♀

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

abnormal head morphology ( J:211773 )

IMPC - CCP-IMG

abnormal tooth morphology ( J:211773 )

IMPC - CCP-IMG

abnormal snout morphology ( J:211773 )

IMPC - CCP-IMG

abnormal head size ( J:211773 )

IMPC - CCP-IMG

increased kidney weight ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

IMPC - CCP-IMG

hematopoietic system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

increased neutrophil cell number ( J:211773 )

IMPC - CCP-IMG

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - CCP-IMG

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

increased NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased memory-marker CD4-positive NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased effector memory T-helper cell number ( J:211773 )

♀

IMPC - CCP-IMG

decreased lymphocyte cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

increased circulating potassium level ( J:211773 )

♂

IMPC - CCP-IMG

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - CCP-IMG

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - CCP-IMG

immune system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

increased neutrophil cell number ( J:211773 )

IMPC - CCP-IMG

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - CCP-IMG

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - CCP-IMG

increased NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased memory-marker CD4-positive NK T cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased effector memory T-helper cell number ( J:211773 )

♀

IMPC - CCP-IMG

decreased lymphocyte cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

IMPC - CCP-IMG

abnormal lymph node morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged lymph nodes ( J:211773 )

♀

IMPC - CCP-IMG

integument

abnormal skin morphology ( J:211773 )

♂

IMPC - CCP-IMG

abnormal skin coloration ( J:211773 )

♀

IMPC - CCP-IMG

nervous system

abnormal brain morphology ( J:211773 )

IMPC - CCP-IMG

hydrocephaly ( J:211773 )

IMPC - CCP-IMG

renal/urinary system

increased kidney weight ( J:211773 )

IMPC - CCP-IMG

reproductive system

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - CCP-IMG

small seminal vesicle ( J:211773 )

♂

IMPC - CCP-IMG

abnormal ovary morphology ( J:211773 )

♀

IMPC - CCP-IMG

skeleton

abnormal cranium morphology ( J:211773 )

♂

IMPC - CCP-IMG

abnormal tooth morphology ( J:211773 )

IMPC - CCP-IMG

abnormal mandible morphology ( J:211773 )

♂

IMPC - CCP-IMG

abnormal maxilla morphology ( J:211773 )

IMPC - CCP-IMG

abnormal zygomatic bone morphology ( J:211773 )

IMPC - CCP-IMG

abnormal vertebrae morphology ( J:211773 )

♀

IMPC - CCP-IMG

abnormal vertebral arch morphology ( J:211773 )

♂

IMPC - CCP-IMG

vertebral fusion ( J:211773 )

IMPC - CCP-IMG

fusion of vertebral arches ( J:211773 )

♀

IMPC - CCP-IMG

abnormal bone structure ( J:211773 )

♂

IMPC - CCP-IMG

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - CCP-IMG

abnormal retina morphology ( J:211773 )

IMPC - CCP-IMG

anophthalmia ( J:211773 )

♀

IMPC - CCP-IMG