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Phenotypes Associated with This Genotype
Genotype
MGI:6717362
Allelic
Composition
Trappc9tm1a(EUCOMM)Wtsi/Trappc9tm1a(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trappc9tm1a(EUCOMM)Wtsi mutation (1 available); any Trappc9 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 16 weeks of age, total brain area is decreased by 12.7%, with a 4.1% decrease in width and a 9.8% decrease in height of the whole brain
• both grey and white matter are affected
• homozygotes show a 11% reduction in adult brain weight relative to wild-type controls
• 12.7% reduction in the areas of the corpus callosum
• 49.1% overall decrease in the area of the substantia nigra
• 15.9% reduction in the area of the thalamus
• 25.7% and 12.1% reduction, respectively, in the area and height of the cingulate cortex
• 17.7% reduction in the area of the fimbria of the hippocampus
• 10% reduction in total area of the cortex
• 11.7% reduction in the thickness of the primary motor cortex

growth/size/body
• females, but not males, show a marked increase in fat mass at 16 weeks of age
• females, but not males, show a moderate increase in lean tissue mass at 16 weeks of age
• in an initial pipeline study, both sexes show an ~1.5-fold increase in body weight at 16 weeks of age, with a lager effect in female mice
• in a second, larger cohort study, females gain significantly more weight starting from 5 weeks of age and cumulatively gain 16% more weight by 16 weeks of age, while males gain 11% more weight by week 16 relative to wild-type controls

homeostasis/metabolism
• both sexes show elevated serum insulin levels
• females, but not males, show elevated plasma cholesterol levels
• females, but not males, show elevated plasma glycerol levels
• females, but not males, show elevated steady-state plasma levels of triglycerides
• females, but not males, show elevated plasma glucose levels during a glucose tolerance test

behavior/neurological
• mice move 22% less than wild-type controls in a 20-min open field test and 21% less in a 10-min elevated plus maze (EPM) test, indicating reduced exploratory activity
• however, no significant difference is seen in the time spent in the periphery and center in the open field, or in the closed versus open arms in EPM tests, suggesting normal anxiety levels
• in a 2-step social recognition test, mice exhibit normal social learning but 24 hours later fail to distinguish a familiar mouse from a novel one in the discrimination test, indicating impaired social memory
• however, mice show normal social preference towards conspecifics in a 3-chamber sociability test

adipose tissue
• females, but not males, show a marked increase in fat mass at 16 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
intellectual disability DOID:1059 J:294716


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory