About   Help   FAQ
Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(DPP4)Yowa mutation (0 available); any Gt(ROSA)26Sor mutation (934 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice are susceptible to infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) strain hCoV-EMC , showing up to 28% weight loss by 5 days post infection (dpi), significant viral titers in the lungs and in the brain, and severe lung disease related to acute respiratory symptoms
• however, no lesions or viral titers are seen in the liver and kidney
• mice treated with a MERS-CoV S-RBD-specific neutralizing antibody (H111-1) are protected from challenge with MERS-CoV, showing decreased viral titers in lungs and reduced weight loss
• mice are also susceptible to infection with high-titer of an optimized pseudotyped MERS-CoV, with younger mice more susceptible than older mice

nervous system
• MERS-CoV-infected mice exhibit perivascular gliosis in the cerebellum, cerebral ganglia and cerebrum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Middle East respiratory syndrome DOID:0080642 J:279060

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.23
The Jackson Laboratory