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Phenotypes Associated with This Genotype
Genotype
MGI:6403447
Allelic
Composition
Gt(ROSA)26Sorem1(DPP4)Yowa/Gt(ROSA)26Sorem1(DPP4)Yowa
Genetic
Background
C57BL/6-Gt(ROSA)26Sorem1(DPP4)Yowa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(DPP4)Yowa mutation (0 available); any Gt(ROSA)26Sor mutation (934 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice are susceptible to infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) strain hCoV-EMC , showing up to 28% weight loss by 5 days post infection (dpi), significant viral titers in the lungs and in the brain, and severe lung disease related to acute respiratory symptoms
• however, no lesions or viral titers are seen in the liver and kidney
• mice treated with a MERS-CoV S-RBD-specific neutralizing antibody (H111-1) are protected from challenge with MERS-CoV, showing decreased viral titers in lungs and reduced weight loss
• mice are also susceptible to infection with high-titer of an optimized pseudotyped MERS-CoV, with younger mice more susceptible than older mice

nervous system
• MERS-CoV-infected mice exhibit perivascular gliosis in the cerebellum, cerebral ganglia and cerebrum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Middle East respiratory syndrome DOID:0080642 J:279060


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory