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Endonuclease-mediated Allele Detail
Symbol: Gt(ROSA)26Sorem1(DPP4)Yowa
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Youchun Wang
MGI ID: MGI:6403442
Synonyms: Gt(ROSA)26Sortm1(SA-hDPP4-tdTomato), R26-hDPP4
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sorem1(DPP4)Yowa page
Strain of Origin:  C57BL/6
Allele Type:    Endonuclease-mediated (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sorem1(DPP4)Yowa expresses 1 gene
Mutation detailsCRISPR/Cas9 technology inserted the full-length human DPP4 cDNA linked to the red fluorescent protein tdTomato by an internal ribosomal entry site into the locus. Expression of the human cDNA is driven by the splice acceptor and A poly(A) sequence and a woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) were added to enhance RNA stability and translation efficiency. Western blot analysis of lung and brain tissue confirmed expression, with highest expression in the lung. (J:279060)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  834 strains or lines available
Original:  J:279060 Fan C, et al., A Human DPP4-Knockin Mouse's Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV. Viruses. 2018 Aug 23;10(9)
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory