Phenotypes Associated with This Genotype

Genotype
MGI:6304452

hm1

• Allelic Composition: Card11^M7Btlr/Card11^M7Btlr
• Genetic Background: C57BL/6J-Card11^M7Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:274762 )

• reduced CD44 expression on peripheral blood T cells

decreased B cell number ( J:274762 )

• reduced frequencies of B cells in the peripheral blood

decreased B-1 B cell number ( J:274762 )

• reduced frequencies of B1 cells in the peripheral blood

decreased central memory CD4-positive, alpha-beta T cell number ( J:274762 )

• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:274762 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD8-positive, alpha-beta T cell number ( J:274762 )

• reduced frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274762 )

• reduced frequencies of B cells in the peripheral blood

• decreased peripheral blood B to T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274762 )

• increased frequencies of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274762 )

• increased frequencies of CD8+ T cells in the peripheral blood

hematopoietic system

abnormal T cell differentiation ( J:274762 )

• reduced CD44 expression on peripheral blood T cells

decreased B cell number ( J:274762 )

• reduced frequencies of B cells in the peripheral blood

decreased B-1 B cell number ( J:274762 )

• reduced frequencies of B1 cells in the peripheral blood

decreased central memory CD4-positive, alpha-beta T cell number ( J:274762 )

• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:274762 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD8-positive, alpha-beta T cell number ( J:274762 )

• reduced frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274762 )

• reduced frequencies of B cells in the peripheral blood

• decreased peripheral blood B to T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274762 )

• increased frequencies of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274762 )

• increased frequencies of CD8+ T cells in the peripheral blood