Analysis Tools
mortality/aging
|
• males exhibited moribund signs (and were thus sacrificed) between 4 and 34 months of age
• females became moribund between 6 and 29 months of age
|
growth/size/body
|
• 8 of 142 mice carried pancreatic cysts, never observed in wild-type controls
|
|
• mice gained less body weight as they aged
|
kidney cyst
(
J:272325
)
|
• 19 of 142 mice that carried liver cysts also had kidney cysts of variable number and size
• incidence of kidney cysts was significantly higher than that in wild-type controls
• no kidney cysts were detected between 3 and 10 months of age
|
liver cyst
(
J:272325
)
|
• 63 of 142 dissected moribund mice (>12 months of age) exhibited liver cysts of variable number and size
• all mice carrying kidney cysts or pancreatic cysts had liver cysts except one mouse
• no liver cysts were detected between 3 and 10 months of age
|
liver/biliary system
liver cyst
(
J:272325
)
|
• 63 of 142 dissected moribund mice (>12 months of age) exhibited liver cysts of variable number and size
• all mice carrying kidney cysts or pancreatic cysts had liver cysts except one mouse
• no liver cysts were detected between 3 and 10 months of age
|
renal/urinary system
kidney cyst
(
J:272325
)
|
• 19 of 142 mice that carried liver cysts also had kidney cysts of variable number and size
• incidence of kidney cysts was significantly higher than that in wild-type controls
• no kidney cysts were detected between 3 and 10 months of age
|
endocrine/exocrine glands
|
• 8 of 142 mice carried pancreatic cysts, never observed in wild-type controls
|
homeostasis/metabolism
| N |
• mice with polycystic livers showed no significant differences in plasma alanine transaminase (ALT) and aspartate transaminase (AST) levels relative to non-diseased mice or wild-type controls
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| polycystic liver disease | DOID:0050770 |
OMIM:174050 |
J:272325 | |
