Ucp2^tm1Lowl
Targeted Allele Detail

Summary

• Symbol: Ucp2^tm1Lowl
• Name: uncoupling protein 2 (mitochondrial, proton carrier); targeted mutation 1, Bradford B Lowell
• MGI ID: MGI:2176058
• Synonyms: Ucp2-
• Gene: Ucp2 Location: Chr7:100142565-100148832 bp, + strand Genetic Position: Chr7, 54.36 cM
• Alliance: Ucp2^tm1Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75196
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced introns 2-7 including the start codon. Northern blot analysis using a full length rat cDNA probe did not detect intact mRNA in any tissues from homozygous mutant mice. Western blot analysis did not detect protein in spleen mitochondria from homozygous mutant mice. (J:75196)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ucp2 Mutation: 39 strains or lines available

References

• Original: J:75196 Zhang CY, et al., Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15;105(6):745-55
• All: 49 reference(s)