Phenotypes Associated with This Genotype

Genotype
MGI:6270159

• Allelic Composition: Tg(Nell1)1Ting/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

enhanced osteoblast differentiation ( J:79106 )

• marker analysis indicates increased osteoblast differentiation at osteogenic fronts of abnormally closing/closed sutures

skeleton

enhanced osteoblast differentiation ( J:79106 )

• marker analysis indicates increased osteoblast differentiation at osteogenic fronts of abnormally closing/closed sutures

premature cranial suture closure ( J:79106 )

• mice exhibit craniosynostosis-like phenotypes ranging from simple to compound synostoses, with anomalies restricted to calvarial bone

• the osteogenic fronts of abnormally closing/closed sutures show calvarial overgrowth and overlap along with increased osteoblast differentiation and reduced cell proliferation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
craniosynostosis		DOID:2340	OMIM:123100 OMIM:182212 OMIM:600593 OMIM:600775 OMIM:604757 OMIM:615314	J:79106