Analysis Tools
growth/size/body
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• mice are on average 20-15% smaller than wild-type littermates
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hematopoietic system
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• mice exhibit increased numbers of eosinophils in the dermis
• expression of chemokines associated with eosinophil immune responses is increased in the blood and skin
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• moderate increase in number of CD3+ T cells in the blood
• however, levels of B lymphocytes, myeloid cells, megakaryocytes, and erythrocytes in the blood are normal
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• disruption of the normal red and white pulp architecture
• increase in infiltration of white blood cells such as myeloid cells and megakaryocytes in the red pulp
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• disruption of the normal red and white pulp architecture
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integument
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• mice show focal dermal inflammatory infiltrates of mononuclear cells consisting primarily of lymphocytes with dispersed macrophages and mast cells
(J:96718)
• some areas of skin in severely affected mice have aggregates of neutrophilic polymorphonuclear leukocytes that form microabscesses within the epidermis
(J:96718)
• mice show an increase in the number of dermal mast cells and CD3+ T lymphocytes in the dermis
(J:96718)
• mice exhibit increased numbers of eosinophils in the dermis
(J:137745)
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• emerging hair appears dull
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sparse hair
(
J:96718
)
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• emerging hair appears sparse
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• severely affected mice display yellow-brown discoloration of the nails
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• in some regions of epidermal thickening, uneven elongation of structures resembling rete pegs extend downward into the dermis; these structures encompass hyperplastic hair follicles
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• mice exhibit larger and more tortuous blood vessels immediately below the epidermis
• horizontal vessels comprising the subpapillary plexus and deeper cutaneous plexus are larger and often extend great distances in close proximity to the hyperproliferative epidermal layer
• increase in density and diameter of blood vessels in the skin, however no change in vessel numbers is seen
• mice treated with doxycycline show reduced vessel diameter and density in the dermis
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• skin has an increased amount and density of cornified material, indicating compact hyperkeratosis
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parakeratosis
(
J:96718
)
|
• skin has areas where nucleated cells are present in the cornified layer, indicating focal parakeratosis
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acanthosis
(
J:96718
)
|
• severely affected mice exhibit zones of hyperplasia due to variable increases in the number of cell layers in the squamous epithelium indicating acanthosis
|
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• mild epidermal thickening in the skin of the ear, head, and back
(J:96718)
• mice treated for 2 weeks with an anti-CD4 antibody do not show improved epidermal hyperplasia, indicating that maintenance of the skin disease is not dependent of CD4+ T lymphocytes
(J:137745)
|
|
• beginning at P5, skin shows extensive erythema
(J:96718)
• adults exhibit patches of thickened erythematous skin around the eyes, snout, ears, and other extensor surfaces including the knuckles of the legs and nape of the neck
(J:96718)
• severity of erythema varies
(J:96718)
• within 7 days of treating adult mice with doxycycline, mice show improved erythematous characteristics
(J:96718)
• mice treated for 2 weeks with an anti-CD4 antibody show improved erythema
(J:137745)
|
scaly skin
(
J:96718
)
|
• beginning at P5, skin shows loosely adherent silver-white scaling
• skin is covered with focal areas of scaling that extend to the tail
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skin lesions
(
J:96718
)
|
• mice show increased genesis of skin lesions at sites of trauma that become large, thickened, and ulcerated
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• skin shows features of psoriasis including epidermal hyperplasia, inflammatory cell accumulation and altered dermal angiogenesis
• within 4 days of doxycycline treatment beginning at P7, mice show improvements in skin and fur appearance
• severely affected mice treated with the immunosuppressive anti-psoriatic agent cyclosporine display improvement in skin phenotype, showing epidermal thinning, reduced dermal cellularity and vascular density
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cardiovascular system
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• dermis exhibits an increase in the number of blood capillaries with dilated and tortuous changes
|
|
• mice exhibit larger and more tortuous blood vessels immediately below the epidermis
• horizontal vessels comprising the subpapillary plexus and deeper cutaneous plexus are larger and often extend great distances in close proximity to the hyperproliferative epidermal layer
• increase in density and diameter of blood vessels in the skin, however no change in vessel numbers is seen
• mice treated with doxycycline show reduced vessel diameter and density in the dermis
|
immune system
|
• mice exhibit increased numbers of eosinophils in the dermis
• expression of chemokines associated with eosinophil immune responses is increased in the blood and skin
|
|
• moderate increase in number of CD3+ T cells in the blood
• however, levels of B lymphocytes, myeloid cells, megakaryocytes, and erythrocytes in the blood are normal
|
|
• disruption of the normal red and white pulp architecture
• increase in infiltration of white blood cells such as myeloid cells and megakaryocytes in the red pulp
|
|
• disruption of the normal red and white pulp architecture
|
|
• mice show focal dermal inflammatory infiltrates of mononuclear cells consisting primarily of lymphocytes with dispersed macrophages and mast cells
(J:96718)
• some areas of skin in severely affected mice have aggregates of neutrophilic polymorphonuclear leukocytes that form microabscesses within the epidermis
(J:96718)
• mice show an increase in the number of dermal mast cells and CD3+ T lymphocytes in the dermis
(J:96718)
• mice exhibit increased numbers of eosinophils in the dermis
(J:137745)
|
vision/eye
|
• older mice sporadically develop a white opacity of the eye indicating age-related cataract
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| psoriasis | DOID:8893 |
OMIM:PS177900 |
J:96718 | |
