Phenotypes Associated with This Genotype

Genotype
MGI:6159890

• Allelic Composition: Slurp2^tm1Lex/Slurp2^tm1Lex
• Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:231067 )

N • no inflammation of paw dermis or epidermis

N • no increase in cytokine expression in paw skin

N • appearance and histology of skin other than paws

increased keratinocyte proliferation ( J:231067 )

• increased BrdU incorporation in basal keratinocytes in paw skin

abnormal epidermis stratum corneum morphology ( J:231067 )

• contains many tiny lipid droplets in volar surface of paws by 6-8 weeks of age

hyperkeratosis ( J:231067 )

• on volar surface of paws by 6-8 weeks of age

abnormal epidermis stratum granulosum morphology ( J:231067 )

• poorly demarcated in volar surface of paws by 6-8 weeks of age

cellular

increased keratinocyte proliferation ( J:231067 )

• increased BrdU incorporation in basal keratinocytes in paw skin

adipose tissue

decreased total fat pad weight ( J:231067 )

• in mice age 7 months fed regular chow

decreased percent body fat/body weight ( J:231067 )

• in mice age 7 months fed regular chow

growth/size/body

slow postnatal weight gain ( J:231067 )

• from age 4 weeks

• food consumption of regular chow

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:231067 )

N • plasma glucose levels

decreased circulating cholesterol level ( J:231067 )

increased oxygen consumption ( J:231067 )

behavior/neurological

limb grasping ( J:231067 )

• clasping of hindlimbs in tail suspension test by 6-8 weeks of age

decreased locomotor activity ( J:231067 )

immune system

immune system phenotype ( J:231067 )

N • no inflammation of paw dermis or epidermis

N • no increase in cytokine expression in paw skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
palmoplantar keratosis		DOID:3390		J:231067