Phenotypes Associated with This Genotype

Genotype
MGI:6121112

• Allelic Composition: Cdyl^tm1.1Yuw/Cdyl^tm1.1Yuw; Emx1^tm1(cre)Yql/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:251551 )

N • behavior in Morris water maze, elevated plus maze, open field and context-dependent and cue-dependent fear conditioning tests

N • locomotor behavior in Morris water maze, elevated plus maze and open field tests

increased susceptibility to pharmacologically induced seizures ( J:251551 )

• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

cellular

abnormal neuronal migration ( J:251551 )

• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2

nervous system

increased susceptibility to pharmacologically induced seizures ( J:251551 )

• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

abnormal neuronal migration ( J:251551 )

• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epilepsy		DOID:1826		J:251551