Cdyl^tm1.1Yuw
Targeted Allele Detail

Summary

• Symbol: Cdyl^tm1.1Yuw
• Name: chromodomain protein, Y chromosome-like; targeted mutation 1.1, Yun Wang
• MGI ID: MGI:6121103
• Synonyms: Cdyl^F
• Gene: Cdyl Location: Chr13:35843816-36058046 bp, + strand Genetic Position: Chr13, 14.39 cM
• Alliance: Cdyl^tm1.1Yuw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 4 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 5. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 5 floxed. (J:251551)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdyl Mutation: 70 strains or lines available

References

• Original: J:251551 Qin R, et al., CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. 2017 Jan 10;18(2):380-390
• All: 2 reference(s)