Phenotypes Associated with This Genotype

Genotype
MGI:6115481

• Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi}; Krt14^tm1(cre)Wbm/Krt14⁺
• Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm
• Cell Lines: EPD0058_1_A11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal keratinocyte differentiation ( J:253986 )

• molecular analysis revealed disrupted keratinocyte differentiation

absent sebaceous gland ( J:253986 )

• at P7, hair follicles in psoriasis-like lesions often lack the sebaceous gland

abnormal head skin morphology ( J:253986 )

• at P1, local thickening of the epidermis, mainly the cornified layer, and scattered ghost (anucleated) cells are mostly evident in the head region

alopecia ( J:253986 )

• at P5, pups exhibit uneven skin thickening with alopecic areas

• at P7, hair follicles in psoriasis-like lesions often lack the shaft

sparse hair ( J:253986 )

• at P5, body and extremities show poorly furred skin

decreased hair follicle number ( J:253986 )

• at P7, hair follicles in psoriasis-like lesions are rare

hyperkeratosis ( J:253986 )

• at P7, the cornified layer is abnormally thickened

parakeratosis ( J:253986 )

• at P7, the thickened cornified layer is characterized by the presence of nuclei and microabscesses

acanthosis ( J:253986 )

• at P7, the epidermal squamous cells exhibit hyperplasia (acanthosis)

thick epidermis ( J:253986 )

• at P1, local thickening of the epidermis, mainly the cornified layer, are mostly evident in the head region

• at P5, body and extremities show unevenly thickened skin

abnormal skin appearance ( J:253986 )

• at P5, pups exhibit abnormal skin appearance with uneven thickening accompanied by alopecic areas

dry skin ( J:253986 )

• at P5, body and extremities show dry skin

scaly skin ( J:253986 )

• over time, psoriasis-like lesions acquire an ichthyosis-like appearance

skin lesions ( J:253986 )

• initial skin lesions are detected microscopically at P1; mice have to be euthanized by P21 due to the severity of skin lesions

psoriasis ( J:253986 )

• at P1, local thickening of the epidermis, mainly the cornified layer, and scattered ghost (anucleated) cells are mostly evident in the head region

• initial skin lesions develop progressively into macroscopic psoriasis-like plaques

• psoriasis-like lesions are variable in size and usually more severe in the dorsal than in the ventral trunk, extremities and head

• over time, psoriasis-like lesions acquire an ichthyosis-like appearance

• psoriatic epidermis exhibits hyperactivation of transcription factor Nrf2 and decreased F-actin levels

• however, mice do not exhibit any outside-in epidermal permeability barrier defects

abnormal skin physiology ( J:253986 )

• skin lesions show increased Ki67 positivity in both the basal and the suprabasal epidermal layers

• at P4, the mutant epidermis shows increased nuclear Nrf2 levels; whereas the number of Nrf2-positive interfollicular keratinocytes declines with age in wild-type epidermis, Nrf2 expression remains ubiquitous in psoriasis-like lesions at P14, indicating Nrf2 hyperactivation

dermatitis ( J:253986 )

• at P7, P14 and P21, inflammatory infiltrations mainly consisting of lymphocytic cells are detected in the dermis

cellular

abnormal keratinocyte differentiation ( J:253986 )

• molecular analysis revealed disrupted keratinocyte differentiation

endocrine/exocrine glands

absent sebaceous gland ( J:253986 )

• at P7, hair follicles in psoriasis-like lesions often lack the sebaceous gland

growth/size/body

abnormal head skin morphology ( J:253986 )

• at P1, local thickening of the epidermis, mainly the cornified layer, and scattered ghost (anucleated) cells are mostly evident in the head region

immune system

dermatitis ( J:253986 )

• at P7, P14 and P21, inflammatory infiltrations mainly consisting of lymphocytic cells are detected in the dermis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:253986