Arpc4^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Arpc4^{tm1c(EUCOMM)Wtsi}
• Name: actin related protein 2/3 complex, subunit 4; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6111539
• Synonyms: Arpc4^f
• Gene: Arpc4 Location: Chr6:113355076-113367409 bp, + strand Genetic Position: Chr6, 52.76 cM
• Alliance: Arpc4^{tm1c(EUCOMM)Wtsi} page
• IMPC: Arpc4 gene page

Mutation origin

• Mutant Cell Line: EPD0058_1_A11
• Germline Transmission: Earliest citation of germline transmission: J:253986
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 113357242 of Chromosome 6 upstream of the critical exon (exon 2) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 113358083. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving exon 2 flanked by loxP sites. (J:253986)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arpc4 Mutation: 13 strains or lines available

References

• Original: J:253986 van der Kammen R, et al., Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2. Development. 2017 Dec 15;144(24):4588-4603
• All: 4 reference(s)