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Phenotypes Associated with This Genotype
Genotype
MGI:5911349
Allelic
Composition
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-TPR/MET,-EGFP)12Tcre/0
Genetic
Background
FVB.Cg-Tg(Myh6-tTA)6Smbf Tg(tetO-TPR/MET,-EGFP)12Tcre
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-tTA)6Smbf mutation (4 available)
Tg(tetO-TPR/MET,-EGFP)12Tcre mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at around 4 weeks after birth (between P25 and P27) when doxycycline (DOX) is removed the day following birth to allow activation of MET in postnatal cardiomyocytes

cardiovascular system
• mice show a massive progressive increase in cardiac hypertrophy from P21 to P27 when DOX is removed the day after birth
• hypertrophy is concentric as indicated by increase in the thickness/radius ratio, left ventricle mass, and left mass normalized to body weight
• treating mice with DOX at P21 rescues the cardiac hypertrophy phenotype
• echocardiography shows reduced left ventricle volumes, in both diastole and systole, in mice when DOX is removed a day after birth
• however, mice do not show systolic dysfunction as assessed by ejection fraction at P27
• mice die with signs of congestive heart failure including lung edema, alopecia, ascites, dyspnea, cyanosis, and lethargy following the removal of DOX the day after birth
• however, ejection fraction is preserved

behavior/neurological
• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
• food intake is normal at P22 but decreases starting from P23 in mice in which DOX was removed the day after birth

growth/size/body
• mice show a massive progressive increase in cardiac hypertrophy from P21 to P27 when DOX is removed the day after birth
• hypertrophy is concentric as indicated by increase in the thickness/radius ratio, left ventricle mass, and left mass normalized to body weight
• treating mice with DOX at P21 rescues the cardiac hypertrophy phenotype
• greater than 27% decrease in body weight at P27 in mice when DOX is removed the day after birth
• decrease in body weight results from a reduction in body weight gain starting from P20
• mice in which DOX was removed the day after birth develop a cardiac cachexia syndrome characterized by weight loss and reduced weight gain, decreased food intake, and skeletal muscle wasting

homeostasis/metabolism
• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
• mice treated with DOX at P21 show rescue of lung edema
• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth

integument
• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth

muscle
• mice showing signs of congestive heart failure show wasted hindlimb muscles and have reduced skeletal muscle weight
• treating mice with DOX at P21 rescues the loss of muscular weight

respiratory system
• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
• mice treated with DOX at P21 show rescue of lung edema
• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congestive heart failure DOID:6000 J:241276


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory