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Phenotypes Associated with This Genotype
Genotype
MGI:5907886
Allelic
Composition
Tg(Myh6-HBEGF)#Iko/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 7 days after DT injection, heart to body weight ratios are about 1.3-fold increased

mortality/aging
• about 80% of mice injected intramuscularly with diphtheria toxin (DT) die within 10 days after DT injection

cardiovascular system
• 1.9-fold increase in cross-sectional areas of cardiomyocytes 14 days after DT injection, indicating that cardiomyocytes which do not express the transgene and survive DT administration, undergo hypertrophic cell growth
• hearts show degenerated cardiomyocytes surrounded by inflammatory cells (macrophages) 7 days after DT injection
• myocardial cell death in DT injected mice that is primarily due to autophagy and not apoptosis
• 7 days after DT injection, heart to body weight ratios are about 1.3-fold increased
• interstitial fibrosis in DT-treated hearts
• 7 days after DT injection, mice exhibit global chamber dilatation with wall thinning
• 7 days after DT injection, mice exhibit a 2.4-fold reduction in fractional shortening
• 7 days after DT injection, mice exhibit an approximate 1.3-fold increase in the left ventricular end-diastolic dimension and a 1.5-1.7-fold decrease in left ventricular wall thickness, and a 2.4-fold reduction in fractional shortening

homeostasis/metabolism
• 7 days after DT injection, mice exhibit atrial thrombus

muscle
• 1.9-fold increase in cross-sectional areas of cardiomyocytes 14 days after DT injection, indicating that cardiomyocytes which do not express the transgene and survive DT administration, undergo hypertrophic cell growth
• hearts show degenerated cardiomyocytes surrounded by inflammatory cells (macrophages) 7 days after DT injection
• myocardial cell death in DT injected mice that is primarily due to autophagy and not apoptosis
• 7 days after DT injection, mice exhibit a 2.4-fold reduction in fractional shortening

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congestive heart failure DOID:6000 J:93335
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:93335


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory