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Tg(Myh6-HBEGF)#Iko
Transgene Detail
Summary
Symbol: Tg(Myh6-HBEGF)#Iko
Name: transgene insertion, Issei Komuro
MGI ID: MGI:5907885
Transgene: Tg(Myh6-HBEGF)#Iko  Location: unknown  
Alliance: Tg(Myh6-HBEGF)#Iko page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-HBEGF)#Iko expresses 1 gene
 
Mutation detailsThe human diphtheria toxin receptor, pro-HB-EGF (precursor of heparin-binding EGF-like growth factor), is under the control of the cardiac-specific alpha-myosin heavy chain promoter. Administration of diphtheria toxin induces ablation of transgene-expressing cardiomyocytes. Two lines were generated, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:93335)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:93335 Akazawa H, et al., Diphtheria toxin-induced autophagic cardiomyocyte death plays a pathogenic role in mouse model of heart failure. J Biol Chem. 2004 Oct 24;279(39):41095-103
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory