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Phenotypes Associated with This Genotype
Genotype
MGI:5907012
Allelic
Composition
Tg(Myh6-cre)TG9Pjay/0
Genetic
Background
involves: FVB/N
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• swim exercise training before cardiac function abnormalities improves lifespan, with mean age increased by about 20% and 16% in males and females, respectively (J:119070)
• maximum life span of females and males is 11 and 13 weeks, respectively (J:198043)
• treatment with captopril, an angiotensin converting enzyme inhibitor, prolongs survival by 1 week in females and by 2 weeks in males (J:198043)
• treatment with metoprolol, a beta1-adrenergic receptor blocker, has a small effect on increased survival (J:198043)

cardiovascular system
• severe pulmonary congestion in end-stage heart failure as indicated by increased lung-to-body weight ratios
• ventricular chamber dilation with a thin myocardial wall
• left ventricular dilation is present by 57 days of age and becomes more pronounced over the next 2 weeks
• mice develop severe dilated cardiomyopathy showing progressive dilation of the left ventricular end-diastolic diameter, worsening systolic function, and a trend towards thinning of the left ventricular wall (J:198043)
• however, no myocardial fibrosis is present (J:198043)
• systolic dysfunction is present by 57 days of age and becomes more pronounced over the next 2 weeks, with decreased fractional shortening and progressive dilation of the left ventricular end-diastolic diameter
• 2-fold increase in incidence of cardiac myocyte apoptosis at 7 weeks of age
• mice become fatigued and sedentary, and show labored breathing before death due to heart failure

cellular
• 2-fold increase in incidence of cardiac myocyte apoptosis at 7 weeks of age

homeostasis/metabolism
• organized thrombi in the left atrium
• peripheral edema
• abdominal ascites

muscle
• mice develop severe dilated cardiomyopathy showing progressive dilation of the left ventricular end-diastolic diameter, worsening systolic function, and a trend towards thinning of the left ventricular wall (J:198043)
• however, no myocardial fibrosis is present (J:198043)
• systolic dysfunction is present by 57 days of age and becomes more pronounced over the next 2 weeks, with decreased fractional shortening and progressive dilation of the left ventricular end-diastolic diameter
• 2-fold increase in incidence of cardiac myocyte apoptosis at 7 weeks of age

respiratory system
• severe pulmonary congestion in end-stage heart failure as indicated by increased lung-to-body weight ratios


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/31/2023
MGI 6.22
The Jackson Laboratory