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Phenotypes Associated with This Genotype
Genotype
MGI:5883506
Allelic
Composition
Genetic
Background
YBR/EiJ
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation

immune system
• although these inbred mice can be infected with MMTV and transmit the virus, virus productionn is attenuated relative to that in other inbreds and over successive generations the infection is cleared through a mechanism requiring T cells

nervous system
• in older animals there is loss of retinal ganglion cells and thinning of the nerve fiber layer that contains their axons, but no other retinal layer abnormality is found
• older mice show optic nerve excavation and remodeling, consistent with glaucomatous neurodegeneration
• by 14 months of age approximately 60% of YBR/EiJ eyes show severe axon loss with extensive gliosis and optic nerve damage

cardiovascular system
• some YBR/EiJ mice develop vascularization of the cornea at 1 year of age

hearing/vestibular/ear
• abnormal tympanogram relative to CBA/CaJ and a panel of 61 inbred strains

vision/eye
• some YBR/EiJ mice develop vascularization of the cornea at 1 year of age
• in older animals there is loss of retinal ganglion cells and thinning of the nerve fiber layer that contains their axons, but no other retinal layer abnormality is found
• older mice show optic nerve excavation and remodeling, consistent with glaucomatous neurodegeneration
• by 14 months of age approximately 60% of YBR/EiJ eyes show severe axon loss with extensive gliosis and optic nerve damage
• YBR/EiJ develop age-related iris stromal atrophy with increasing iris depigmentation and iris stromal cell loss but no iris pigment epithelial cell loss
• by 9 months of age itis stromal atrophy causes thinning of the iris stroma and peripupillary atrophy with increasing transillumination defects
• as these mice age the deteriorating iris stroma causes released pigment and debris to accumulate at the iridocorneal angle, focal tissue adhesions form, angle closure occurs and there is a block of aqueous humor drainage
• beginning at approximately 6 to 7 months of age and increasing with age, apparently as a result of pigment debris released from deteriorating iris stroma accumulating at the iridocorneal angle


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory