Analysis Tools
skeleton
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• as early as 2 weeks, tamoxifen-treated mice exhibit progressive, heterotopic ossification (HO) in the sternum, caudal vertebrae, hip joint and hindlimb resulting in fusion between the heterotropic bone and native skeletal elements
• mature heterotropic bone contain bone marrow and resemble normal bone
• however, treatment with broad-acting BMP and activin blockers ACVR2A-Fc and ACVR2B-Fc, alone or in combination, inhibits or ameliorates HO phenotype
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| fibrodysplasia ossificans progressiva | DOID:13374 |
OMIM:135100 |
J:234069 | |
