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Phenotypes Associated with This Genotype
Genotype
MGI:5784778
Allelic
Composition		 Hrastm1Jaf/Hrastm1Jaf
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Jaf mutation (0 available); any Hras mutation (29 available)
Ptentm2.1Ppp mutation (0 available); any Pten mutation (86 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased thyroid tumor incidence ( J:231492 )
• mice develop poorly differentiated thyroid cancer

neoplasm
increased thyroid tumor incidence ( J:231492 )
• mice develop poorly differentiated thyroid cancer

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
thyroid cancer DOID:1781 J:231492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory