Analysis Tools
behavior/neurological
head tossing
(
J:230572
)
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• Background Sensitivity: although only approximately 70 of homozygotes on mixed C57BL/6J x C3HeB/FeJ background display head tossing and circling, it is higher on the pure C57BL/6J background
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• Background Sensitivity: although only approximately 70 of homozygotes on mixed C57BL/6J x C3HeB/FeJ background display head tossing and circling, it is higher on the pure C57BL/6J background
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endocrine/exocrine glands
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• at 16 weeks of age only a few normal follicles are found, there are highly proliferating epithelial cells that give rise to goiters, and the T4 levels are significantly lower than normal especially at younger ages
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vision/eye
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• fluorescein angiography shows choroidal neovacularization with leakage, and newly formed vessels are evident by histology at 6 and 16 weeks of age, although retonograms show normal amplitudes at 16 weeks of age
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• retina degeneration in older homozygotes
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retina spots
(
J:230572
)
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• scattered depigmented spots are found by 6 weeks of age and large depigmented areas are found by 16 weeks of age
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hearing/vestibular/ear
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• inner and outer hair cells are normal at 1 month of age, but by 5 weeks of age some outer hair cells are missing stereocilia bundles and this is greater near the apex and base of the cochlea than the mid-region
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• at 1 month of age the cochlear structures are fairly normal, but by 3 months of age the organ of Corti is completely degenerated
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• cross-sectional analysis of the crista ampullaris shows loss of vestibular hair cells
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• by 1 month of age ABR thresholds are approximately 40 dB higher at all frequencies, and by 6 months of age there is no detectable ABR even at 100 dB
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growth/size/body
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• females and, to a lesser degree, males have a lower body weight as assessed between 4 and 6 weeks of age
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reproductive system
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• approximately 30 to 50% of mature spermatozoa have tails that are bent at the mid-piece
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• although all meiotic stages are present in the seminiferous tubules, the number of maturing sperm cells is reduced in homozygotes by approximately 40%
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homeostasis/metabolism
nervous system
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• inner and outer hair cells are normal at 1 month of age, but by 5 weeks of age some outer hair cells are missing stereocilia bundles and this is greater near the apex and base of the cochlea than the mid-region
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• cross-sectional analysis of the crista ampullaris shows loss of vestibular hair cells
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cellular
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• approximately 30 to 50% of mature spermatozoa have tails that are bent at the mid-piece
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• although all meiotic stages are present in the seminiferous tubules, the number of maturing sperm cells is reduced in homozygotes by approximately 40%
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cardiovascular system
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• fluorescein angiography shows choroidal neovacularization with leakage, and newly formed vessels are evident by histology at 6 and 16 weeks of age, although retonograms show normal amplitudes at 16 weeks of age
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