Phenotypes Associated with This Genotype

Genotype
MGI:5703863

• Allelic Composition: Dp(16Lipi-Zbtb21)1TybEmcf/0
• Genetic Background: B6JNimr.129P2-Dp(16Lipi-Zbtb21)1TybEmcf/Nimr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:227899 )

• fewer than expected mice are produced

cardiovascular system

abnormal cardiac outflow tract development ( J:227899 )

• unwedged morphology of the left outflow tract

abnormal heart development ( J:227899 )

• at E12.5, the size of the dorsal mesenchymal protrusion is reduced compared to in wild-type mice

• at E14.5, mice exhibit congenital

• however, dorsal mesenchymal protrusion is largely unaffected

double outlet right ventricle ( J:227899 )

• with subaortic communication

overriding aortic valve ( J:227899 )

atrioventricular septal defect ( J:227899 )

• with two bridging leaflets across the single atrioventricular junction

• he ventricular shunt is observed

• however, no atrial shunt is observed

ventricular septal defect ( J:227899 )

perimembraneous ventricular septal defect ( J:227899 )

muscular ventricular septal defect ( J:227899 )

nervous system

hydrocephaly ( J:227899 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:227899