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Phenotypes Associated with This Genotype
Genotype
MGI:5688717
hm3
Allelic
Composition		 Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chiasmata formation ( J:216866 )
• severely reduced chiasmata and accumulate univalent chromosomes in meiosis I

cellular
abnormal chiasmata formation ( J:216866 )
• severely reduced chiasmata and accumulate univalent chromosomes in meiosis I

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory