Phenotypes Associated with This Genotype

Genotype
MGI:5636497

cx38

• Allelic Composition: a/a; Pax3^Sp-1H/Pax3^Sp-1H
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

incomplete rostral neuropore closure ( J:19818 )

• in half of E13.5 embryos examined, parts of the rostral neural tube are not closed properly

nervous system

incomplete rostral neuropore closure ( J:19818 )

• in half of E13.5 embryos examined, parts of the rostral neural tube are not closed properly

abnormal lateral ventricle morphology ( J:19818 )

• incomplete closure of anterior neuropore leads to collapse of lateral ventricles

absent choroid plexus ( J:19818 )

• noted in lateral ventricles of E16.5 fetuses

abnormal cerebral cortex morphology ( J:19818 )

• E16.5 fetuses do not show lamination in the cerebral cortex

absent olfactory bulb ( J:19818 )

• noted at E16.5 of gestation

exencephaly ( J:19818 )

• in some mutants the rostral nueral tube does not close leaving the hindbrain, midbrain, and most of the forebrain exposed