Phenotypes Associated with This Genotype

Genotype
MGI:5634715

• Allelic Composition: Emx1^tm1(cre)Ito/Emx1⁺; Tg(CAG-Mtor*)#Atai/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased neuron apoptosis ( J:211789 )

• neuronal progenitor cell death is seen at E12

• however, proliferation of neuronal progenitor cells is not affected

nervous system

increased neuron apoptosis ( J:211789 )

• neuronal progenitor cell death is seen at E12

• however, proliferation of neuronal progenitor cells is not affected

small hippocampus ( J:211789 )

abnormal cerebral cortex morphology ( J:211789 )

• decrease in cortical size, although cortical structure is preserved

• cortical atrophy is already seen at E12 and the cerebral cortex is atrophied in adulthood

decreased neuronal precursor cell number ( J:211789 )

• the number of Tbr2+ subventricular zone progenitors is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
tuberous sclerosis		DOID:13515	OMIM:PS191100	J:211789