Phenotypes for Pas17 Poli MGI:5582779 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pas17^C57BL/6JBy/Pas17^C57BL/6JBy Poli^tm1.1Lgh/Poli^tm1.1Lgh
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pas17^C57BL/6JBy mutation (0 available); any Pas17 mutation (0 available)
Poli^tm1.1Lgh mutation (0 available); any Poli mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:212610 )

• increase in tumor number induced by urethane that is not as severe as in mice heterozygous for Par2^A/J, Poli^tm1Lgh, and Pas1^A/J/Pas1^C57BL/6J

• however, tumor size is normal

cellular

abnormal cell physiology ( J:212610 )

• increased urethane-induced DNA mutations in Kras

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:212610 )

• increase in tumor number induced by urethane that is not as severe as in mice heterozygous for Par2^A/J, Poli^tm1Lgh, and Pas1^A/J/Pas1^C57BL/6J

• however, tumor size is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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