Phenotypes Associated with This Genotype

Genotype
MGI:5578522

• Allelic Composition: Tg(TG-NRAS*Q61K)#Msnt/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased thyroid adenoma incidence ( J:210016 )

• 11% of mice develop follicular adenoma with a mixed papillary and follicular architecture by 18 months of age

increased thyroid carcinoma incidence ( J:210016 )

• 29.5% of mice develop follicular carcinoma by 18 months of age, showing well-differentiated follicular or mixed papillary-follicular malignant component invading the stroma

• 10% of mice (25% of mice that have carcinoma) develop invasive poorly-differentiated carcinoma by 18 months of age

• however, squamoid, spindle and giant cell patterns of growth typical of undifferentiated carcinomas are not seen

increased metastatic potential ( J:210016 )

• metastasis is seen within the parenchyma of the liver, the lung, or in the femur in some mice with poorly-differentiated carcinoma

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:210016 )

• follicular cell hyperplasia is characterized by large, indistinct areas of small follicles with scant colloid and tall epithelial cells

increased thyroid adenoma incidence ( J:210016 )

• 11% of mice develop follicular adenoma with a mixed papillary and follicular architecture by 18 months of age

increased thyroid carcinoma incidence ( J:210016 )

• 29.5% of mice develop follicular carcinoma by 18 months of age, showing well-differentiated follicular or mixed papillary-follicular malignant component invading the stroma

• 10% of mice (25% of mice that have carcinoma) develop invasive poorly-differentiated carcinoma by 18 months of age

• however, squamoid, spindle and giant cell patterns of growth typical of undifferentiated carcinomas are not seen

homeostasis/metabolism

increased thyroid-stimulating hormone level ( J:210016 )

• 60% of mice show on average a 2.5-fold higher levels of thyroid-stimulating hormone (TSH) at 4-8 months of age

• at 10-16 months of age, 40% of mice show TSH levels 1.5-fold higher than in controls

• however, T4 levels are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid gland follicular carcinoma		DOID:3962	OMIM:188470	J:210016