Phenotypes Associated with This Genotype

Genotype
MGI:5573240

• Allelic Composition: Adgrg1^tm1Lex/Adgrg1⁺
• Genetic Background: B6.129S5-Adgrg1^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased male germ cell number ( J:166517 )

endocrine/exocrine glands

abnormal testis morphology ( J:166517 )

• fragemented basement membrane in testis, mainly on the mesonephric side

abnormal seminiferous tubule morphology ( J:166517 )

• disrupted in some regions

abnormal Sertoli cell morphology ( J:166517 )

• Sertoli cells were scattered in the defective areas of the testes, instead of forming tubular structures

disorganized testis cords ( J:166517 )

• disrupted on the mesonephric side of the gonad

small testis ( J:166517 )

reproductive system

decreased male germ cell number ( J:166517 )

abnormal testis morphology ( J:166517 )

• fragemented basement membrane in testis, mainly on the mesonephric side

abnormal seminiferous tubule morphology ( J:166517 )

• disrupted in some regions

abnormal Sertoli cell morphology ( J:166517 )

• Sertoli cells were scattered in the defective areas of the testes, instead of forming tubular structures

disorganized testis cords ( J:166517 )

• disrupted on the mesonephric side of the gonad

small testis ( J:166517 )

reduced male fertility ( J:166517 )

• Background Sensitivity: on a C57BL/6J congenic background, reduced male fertility is seen compared to a mixed C57BL/6J and 129S5 background

• Background Sensitivity: progressive severity with age