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Phenotypes Associated with This Genotype
Genotype
MGI:5563662
Allelic
Composition
Tg(KRT14-CASP1)1Miz/0
Genetic
Background
involves: C57BL/6
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than 80% of mice die within 6 days after Propionibacterium acnes administration compared to none of wild-type mice

growth/size/body

integument
• keratinocytes in the lesions show eosinophilic necrosis with nuclear condensation, indicating apoptosis
• mice eventually develop papillomatosis with intercellular edema
• severe erosive dermatitis is seen at 8 weeks of age, followed by reepithalization and lichenoid changes (J:78602)
• mast cell number is increased in the dermal infiltrates (J:78602)
• mice exhibit chronic active dermatitis at 8 weeks of age from 8 weeks of age, mice develop focal dermatitis around their eyes, which rapidly develops into severe erosive dermatitis and extends onto face, ear, neck, neck, trunk, and legs within a few weeks (J:79706)
• dermis of ulcers is characterized by infiltration of many mononuclear cells (J:79706)
• loss of facial hair and extremity hair is seen by 16 weeks of age
• mice eventually develop papillomatosis with intercellular edema
• mice eventually exhibit parakeratotic scale-crust in the epidermis (J:78602)
• seen by 10 weeks of age (J:79706)
• mice eventually develop prominent acanthosis
• mice develop inflammatory skin lesion with high concentration of IgE
• occasional skin ulcers are seen at 8 weeks of age and although reepithalization occurs, erosion occurs and ulcers relapse
• after 16 weeks of age, multiple skin ulcers form and the ear and eyelids are deformed
• thick epidermis around ulcers at 10 weeks of age shows psoriasis-like changes including parakeratosis

immune system
• proportion of neutrophils, as determined by Gr-1+ Mac-1+ cells, is elevated in the spleen
• splenic lymphocytes show a lower proportion of T cells compared to wild-type mice
• isolated CD4+ T cells produce more IL-3, Il-4, and IL-5, but less IFN-gamma, in response to immobilized anti-CD3, compared to wild-type mice
• high concentration of IL-18 in the circulation at 4 weeks after birth, that gradually increases with growth (J:79706)
• severe erosive dermatitis is seen at 8 weeks of age, followed by reepithalization and lichenoid changes (J:78602)
• mast cell number is increased in the dermal infiltrates (J:78602)
• mice exhibit chronic active dermatitis at 8 weeks of age from 8 weeks of age, mice develop focal dermatitis around their eyes, which rapidly develops into severe erosive dermatitis and extends onto face, ear, neck, neck, trunk, and legs within a few weeks (J:79706)
• dermis of ulcers is characterized by infiltration of many mononuclear cells (J:79706)
• P. acnes treated mice develop fatal hepatitis and show an increase in IFN-gamma levels following P. acnes infection that peaks at 4 days after infection that is not seen in wild-type mice
• treatment with a neutralizing anti-IL18 antibody completely rescues mice from fatal liver injury
• susceptibility to P. acnes induced liver injury is not different before and after the onset of skin changes
• more than 80% of mice die within 6 days after Propionibacterium acnes administration compared to none of wild-type mice

homeostasis/metabolism
• elevation of plasma histamine levels
• high concentration of IL-18 in the circulation at 4 weeks after birth, that gradually increases with growth (J:79706)
• mice eventually develop papillomatosis with intercellular edema

cellular
• keratinocytes in the lesions show eosinophilic necrosis with nuclear condensation, indicating apoptosis

behavior/neurological
• mice frequently scratch their skin, particularly the skin lesion

hematopoietic system
• proportion of neutrophils, as determined by Gr-1+ Mac-1+ cells, is elevated in the spleen
• splenic lymphocytes show a lower proportion of T cells compared to wild-type mice
• isolated CD4+ T cells produce more IL-3, Il-4, and IL-5, but less IFN-gamma, in response to immobilized anti-CD3, compared to wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
atopic dermatitis DOID:3310 OMIM:603165
OMIM:PS603165
J:78602


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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory