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Phenotypes Associated with This Genotype
Genotype
MGI:5563040
cx8
Allelic
Composition		 Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu/Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu
Il6tm1Kopf/Il6tm1Kopf
Genetic
Background		 B6.Cg-Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu Il6tm1Kopf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu mutation (0 available); any Ash1l mutation (138 available)
Il6tm1Kopf mutation (10 available); any Il6 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:208213 )
• reduced inflammation compared with Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu homozygotes
increased susceptibility to induced arthritis ( J:208213 )
• compared with Il6tm1Kopf homozygotes

skeleton
increased susceptibility to induced arthritis ( J:208213 )
• compared with Il6tm1Kopf homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory