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Phenotypes Associated with This Genotype
Genotype
MGI:5562927
cn4
Allelic
Composition		 Gata4tm1.1Sad/Gata4+
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (37 available)
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (36 available)
Tg(Wt1-cre)1Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:206877 )
• mutants are viable through E15.5, with a small number recovered at weaning

cardiovascular system
abnormal heart layer morphology ( J:206877 )
• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory