Phenotypes Associated with This Genotype

Genotype
MGI:5558945

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Fgf14^{Tg(tetO-MAPT*P301L)4510Kha}/Fgf14⁺
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:207366 )

• progressive decrease in percent of time spent freezing in response to unconditioned stimulus beginning at 2 months of age

impaired cued conditioning behavior ( J:207366 )

• progressive decrease in percent of time spent freezing in response to conditioned stimulus beginning at 6 months of age

increased exploration in new environment ( J:207366 )

abnormal anxiety-related response ( J:207366 )

decreased anxiety-related response ( J:207366 )

• amount of time spent in open arms of elevated plus maze is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months

• higher ratio of time spent in open not closed arms relative to nontransgenic mice at 10 months of age, but not 2 or 6 months

• exploration of light chamber is increased relative to nontransgenic mice at 6 months of age, but not 2 or 10 months

• higher ratio of time spent in light not dark relative to nontransgenic miceat 10 months of age, but not 2 or 6 months

increased anxiety-related response ( J:207366 )

• decreased tendency to explore the center of the open field relative to nontransgenic mice

increased locomotor activity ( J:207366 )

• mice exhibit progressive hyperactivity in open field analysis and elevated plus maze

• total distance travelled in open field assay is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months

• average speed is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months

• total time spent mobile is increased relative to nontransgenic mice at 6 and 10 months of age, but not 2 months

nervous system

neurofibrillary tangles ( J:207366 )

• neurofibrilliary tangles are observed by immunostaining in the CA1 region of the hippocampus beginning at 6 months of age and progressing to an extensive pathology by 11 months of age

• neurofibrilliary tangles are observed by immunostaining in the amygdala beginning at 2 months of age and progressing to an extensive pathology by 10 months of age

tau protein deposits ( J:207366 )

• tau burden increases with age in the amygdala and CA1 region of the hippocampus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
frontotemporal dementia		DOID:9255	OMIM:600274	J:207366