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Transgenic Allele Detail
Symbol: Fgf14Tg(tetO-MAPT*P301L)4510Kha
Name: fibroblast growth factor 14; transgene insertion 4510, Karen Hsiao Ashe
MGI ID: MGI:4819866
Synonyms: rTg4510, rTgP301L, Tg4510, Tg(tauP301L)4510, Tg(tetO-MAPT*P301L)4510Kha, Tg(tetO-MAPT*P301L)#Kha, Tg(tetO-TauP301L)4510
Gene: Fgf14  Location: Chr14:124215319-124914539 bp, - strand  Genetic Position: Chr14, 66.18 cM
Alliance: Fgf14Tg(tetO-MAPT*P301L)4510Kha page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Null/knockout)
Inducer:    doxycycline/tetracycline
Mutations:    Insertion, Intragenic deletion
Fgf14Tg(tetO-MAPT*P301L)4510Kha expresses 1 gene
Fgf14Tg(tetO-MAPT*P301L)4510Kha expression driven by 1 gene
Mutation detailsThe human four-repeat tau gene lacking the amino-terminal sequences (4R0N) containing the frontotemporal dementia-associated P301L mutation sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and inserted into the context of the mouse prion protein gene (prnp) exons 2-3 transcribed but untranslated sequences. When mice are crossed with a line expressing a tTA transgene, Tg(Camk2a-tTA)1Mmay, these mice show the doxycycline sensitivity for transgene suppression. At least two bitransgenic lines were established that can be suppressed with doxycycline. One bitransgenic mouse strain expressing approximately 13 units of tauP301L transgene was named rTg(tau P301L)4510 and was analyzed further. Line 4510 inserted into the gene at 124457842-124702169 (Build GRCm38/mm10) resulting in a 244,327 bp deletion. (J:99626)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fgf14 Mutation:  35 strains or lines available
Original:  J:99626 Santacruz K, et al., Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005 Jul 15;309(5733):476-81
All:  138 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.23
The Jackson Laboratory