Analysis Tools
hematopoietic system
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• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
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• bones are pale at 20 weeks of age, suggesting decreased erythropoiesis
• erythroid TER-119+ cells are reduced in the bone marrow but a compensatory increase is seen in the spleen at 20 weeks of age
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• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age
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• liver shows extramedullary hematopoiesis at 20 weeks of age with highly atypical megakaryocytes, but islands with myelopoeisis and erythropoiesis are also seen
• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
• hematopoietic cells, including megakaryocytes are seen in the lung at 20 weeks of age
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• bone marrow shows hypercellularity with trilineage hyperplasia at 20 weeks of age
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• increase in numbers of megakaryocytes in the spleen and bone marrow at 20 weeks of age, most with morphological abnormalities such as hyperchromatic, hyperlobulated nuclei, and bizarre nuclear configuration, and often forming clusters
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• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
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• collagen-based culture indicates a small increase in CFU-MK in bone marrow and a massive expansion of CFU-MK in the spleen
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• slight decrease in hemoglobin at 20 weeks of age but is normal at 10 weeks of age
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• slight increase in neutrophils at 10 and 20 weeks of age
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• thrombocytosis is seen at 10 weeks of age, with a massive increase in platelets at 20 weeks of age
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• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
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• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
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• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age
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• seen at 20 weeks of age
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immune system
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• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age
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• slight increase in neutrophils at 10 and 20 weeks of age
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• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
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• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
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• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age
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• seen at 20 weeks of age
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skeleton
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• dilated sinusoids with intrasinusoidal hematopoiesis are seen in the bone marrow at 20 weeks of age
• myeloid cells are the predominant cell population in the bone marrow
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• presence of myelofibrosis at 20 weeks of age
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growth/size/body
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| essential thrombocythemia | DOID:2224 |
OMIM:187950 OMIM:601977 OMIM:614521 |
J:134364 | |
