Phenotypes Associated with This Genotype

Genotype
MGI:5545905

cn5

• Allelic Composition: Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased cerebellar granule cell precursor proliferation ( J:205551 )

• fewer mitotic granule cell in the cerebellum at P5

hydrocephaly ( J:205551 )

• progressive in most mice by 3 to 6 months

enlarged brain ventricles ( J:205551 )

• in most mice at P10 to P15

abnormal cerebellar layer morphology ( J:205551 )

• ectopic lamination at E17.5

• intermingling layers at P5

ectopic Purkinje cell ( J:205551 )

• at E17.5

• in the white matter at P5

delaminated Purkinje cell layer ( J:205551 )

• at P5

small cerebellum ( J:205551 )

• reduced area at P5

growth/size/body

postnatal growth retardation ( J:205551 )

• mice fail to thrive

cellular

decreased cerebellar granule cell precursor proliferation ( J:205551 )

• fewer mitotic granule cell in the cerebellum at P5